MGK 264

NOMENCLATURE
Trade name: MGK 264
IUPAC name: N-(2-ethylhexyl)-8,9,10-trinorborn-5-ene-2,3-dicarboximide; N-(2-ethylhexyl)bicyclo[2.2.1]hept-5-ene-2,3-dicarboximide
Chemical Abstracts name: 2-(2-ethylhexyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
Other names: N-octylbicycloheptenedicarboximide
CAS RN: [113-48-4]

PHYSICAL CHEMISTRY
Composition: The active ingredient is a 55:45 mixture of cis- and trans- isomers, both of which are biologically active. Tech. grade is 98% pure; main impurity 2-ethylhexanol. Mol. wt.: 275.4; M.f.: C₁₇H₂₅NO₂; Form: Liquid. M.p.: <-20 ^oC; B.p.: 150 ^oC/2 mmHg. V.p.: 2.4 mPa (25 ^oC). KOW: logP = 3.61 (cis- isomer); 3.80 (trans- isomer). S.g./density: 1.046 (20 ^oC). Solubility: Practically insoluble in water. Miscible with most organic solvents including petroleum oils, fluorinated hydrocarbons, also DDT and HCH. Stability: Stable to light and heat. No hydrolysis after 30 d at pH 5-9.

APPLICATIONS
Uses: A synergist for pyrethroids in aerosol sprays for household and veterinary use.
Formulation types: Aerosol concentrates; DP.

MAMMALIAN TOXICOLOGY
Oral: Acute oral LD₅₀ for male rats 4990, female rats 4220 mg/kg.
Skin and eye: Acute percutaneous LD₅₀ for rabbits 470 mg/kg.
Inhalation: LC₅₀ (4 h) for rats >4.08 mg/l.
NOEL: for rats ₅₀ mg/kg daily. NOEL for oncogenicity 450 mg/kg daily.
Toxicity class: WHO (a.i.) III

ECOTOXICOLOGY
Birds: LC₅₀ (8 d) for mallard ducks and bobwhite quail >5620 mg/kg diet.
Fish: LC₅₀ (96 h) for rainbow trout 1.4, bluegill sunfish 2.4 mg/l.
Daphnia: LC₅₀ (48 h) 2.3 mg/l.

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